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RA no RA), keeping other covariates set at their naturally occurring values.CIs were calculated using the delta method and allowed correlation between observations (analogous to the robust option) to estimate the logistic regression [11].

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Outcomes and baseline co-morbidities were established using validated Current Procedural Terminology and ICD-9 searches [9, 10].Table 1 displays the baseline characteristics of our final sample of 256 331 Medicare beneficiaries with diabetes mellitus, further categorized as 5572 with RA and 250 759 without RA.Diabetes patients with RA were more likely to be female and have received Medicaid compared with diabetes patients without RA.Furthermore, when compared with other vascular co-morbidities, RA was the only condition linked with a lower prevalence of diabetic retinopathy, while other conditions such as ischaemic heart disease, PVD and CKD each independently increased the risk for diabetic retinopathy (Fig. When comparing a separate model restricted to RA patients without a history of other diabetes complications, the significantly lower prevalence of diabetic retinopathy persisted compared with diabetes patients without RA [OR 0.71 (95% CI 0.58, 0.87), data not shown].

Adjusted risk ratios for diabetic retinopathy The vertical line indicates the reference group at ARR = 1.0.

However, aspirin is no longer a RA mainstay, prompting interest in re-examining this relationship.

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